Dr Michelle de Silva
BSc (La Trobe), BSc(Hons) (Uni Melb), PhD (Uni Melb) |
|
Position |
Centre Manager |
Phone Number |
61 3 8344 6620 |
Fax Number |
61 3 8344 8824 |
Office Location |
G01, Bld 167 |
Academic Qualifications
- 1992: Bachelor of Science - La Trobe University, Majors: GENETICS AND BIOCHEMISTRY
- 1993: Bachelor of Science Honours - The University of Melbourne Department of Medicine (Austin & Repatriation Medical Centre) Project: The dominance of multidrug resistance
- 2000: Doctor of Philosophy - The University of Melbourne Department of Medicine (Austin & Repatriation Medical Centre) Thesis: Characterisation of a unique karyotypic abnormality in a drug-resistant leukaemia cell line
Research Interests
- Regeneration of Neural and Auditory Cells
- Stem Cell Biology
- Tissue Engineering
- Genetic Aspects of Health and Disease
Involvement in Professional Societies
2005-2006 Co-President: Postdoctoral and Advanced Clinical Trainee (PACT) association, Murdoch Childrens Research Institute/Royal Children’s Hospital
2003-2005 Treasurer: Postdoctoral and Advanced Clinical Trainee (PACT) association, Murdoch Childrens Research Institute/Royal Children’s Hospital
2004- Honorary member: Genetics Education Unit, Murdoch Childrens Research Institute
2003- Member: International Society for Stem Cell Research
2000- Member: The Australian Society for Medical Research
- ASMR Medical Research Week® Public Outreach Convenor 2007-2008
- ASMR Medical Research Week® Victorian Metropolitan Secondary Schools Talks Co-ordinator 2006
- ASMR Medical Research Week® Victorian Public Relations Officer 2004
1996- Member: The Human Genome Organisation
- Member: Human Genetics Society of Australasia
Recent Publications
- Efron, D., Delatycki, M.B., de Silva, M.G., Langbein, A., Slaghuis, W., Larson, A., Dahl, H.-H.M. and Forrest, S. A novel pericentric inversion of chromosome 3 co segregates with a developmental-behavioural phenotype. Journal of Medical Genetics,40:e15 (http://www.jmedgenet.com/cgi/content/full/40/2/e15), 2003.
- de Silva, M.G. (corresponding author) , Elliott, K., Dahl, H.-H.M., Fitzpatrick, E., Wilcox, S., Delatycki, M., Williamson, R., Efron, D., Lynch, M., and Forrest, S.M. Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype. Journal of Medical Genetics, 40(10):733-740, 2003.
- Hildebrand, M., de Silva, M.G., Klockars, T., Rose, E., Price, M., Smith, R.J.H., McGuirt, W.T., Christopoulos, H., Petit, C., Dahl, H.-H.M. Characterization of DRASIC in the mouse inner ear. Hearing Research, 190(1-2):149-160 (2004).
- Hildebrand, M.S., de Silva, M.G., Klockars, T., Solares, C.A., Hirose K., Smith, J.D., Patel, S.C., Christopoulos, H. and Dahl, H.-H.M. Expression of the carrier protein apolipoprotein D in the mouse inner ear. Hearing Research,200(1-2):102-114 (2005).
- Hildebrand, M.S., Dahl, H.-H.M., Hardman, J., Coleman, B., Shepherd, R.K. and de Silva, M.G.(corresponding author). Survival of partially differentiated mouse ES cells in the scala media of the adult guinea pig cochlea. The Journal of the Association for Research in Otolaryngology, 6(4):341-354, 2005.
- Coleman, B., Hardman, J., Coco, A., Epp S., de Silva, M., Crook, J. and Shepherd, R. Fate of embryonic stem cells transplanted into the deafened mammalian cochlea. Cell Transplantation, 15(5):369-380, 2006.
- de Silva, M.G. (corresponding author) , Hildebrand, M.S., Christopoulos, H., Newman, M.R., Bell, K., Ritchie, M., Smyth, G.K. and Dahl, H.-H.M. Gene expression changes during step-wise differentiation of embryonic stem cells along the inner ear hair cell pathway. Acta Oto-Laryngologica, 126(11):1148-1157, 2006.
- Dahl, H.-H.M., Manji, S.M., de Silva, M., Peverelli, M. and Hildebrand, M. Genetic aspects of hearing loss. Acoustics Australia, 34(1):25-29, 2006.
- Hildebrand, M.S., de Silva, M.G., Gardner, R.J., Rose, E., de Graaf, C.A., Bahlo, M. and Dahl, H.-H.M. Cochlear implants for DFNA17 deafness. The Laryngoscope,116(12):2211-2215, 2006.
- KN, H., Pal, S., Yarski, M., Baker, E.K., Chow, M.Z., de Silva, M.G., Okabe, J., Wang, L., Jones, P.L., Sif, S. and El-Osta, A. Reply to “Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex”. Nature Genetics, 38(9):964-967, 2006.
- Coleman, B., Fallon, J.B., Pettingill, L.N., de Silva, M.G., and Shepherd, R.K. Auditory hair cell explant co-culture promotes the differentiation of stem cells into bipolar neurons. Experimental Cell Research, 313 (2): 232-243, 2007.
- Hildebrand, M.S., de Silva, M.G., Klockars, T., Campbell, C.A., Smith, R.J.H. and Dahl, H.-H.M. Gene expression profiling analysis of the inner ear. Hearing Research, 225(1-2): 1-10, 2007.
- Coleman, B., de Silva, M.G. and Shepherd, R.K. The potential of stem cells for auditory neuron generation and replacement. Stem Cells (published online 26 th July, 2007).